Do precursor polyp burdens help distinguish Lynch versus non-Lynch microsatellite unstable colorectal cancers?
نویسندگان
چکیده
منابع مشابه
Do precursor polyp burdens help distinguish Lynch versus non-Lynch microsatellite unstable colorectal cancers?
Background Microsatellite instability (MSI) within colorectal cancers (CRC) may develop through inherited germline mutations in mismatch repair (MMR) genes (Lynch Syndrome) or sporadic epigenetic methylation of tumor suppressor or repair genes (methylator pathway). Although the molecular mechanisms in each pathway have been described, their associated precursor polyp burdens are not well-define...
متن کاملLynch Syndrome (HNPCC) and Microsatellite Instability
A departure from the concept of simple adenoma to carcinoma sequence is the realization that colorectal cancer (CRC) develops through at least two major molecular pathogenic pathways, namely chromosomal instability (CIN) and microsatellite instability (MSI) [1,2]. The mechanisms underlying CIN might have been the first to be deciphered but they are just being understood in detail. It is propose...
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Women with hereditary non-polyposis colorectal cancer (HNPCC)/Lynch syndrome have a high risk for endometrial cancer (EC) and frequently present with a gynaecological cancer as their first or sentinel malignancy. Identification of these patients is important given their personal and family risk for synchronous and metachronous tumours. Modalities to detect ECs for the possibility of HNPCC inclu...
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BACKGROUND Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance. In particular, patients with Lynch syndrome, hereditary nonpolyposis colorectal cancer (HNPCC), have an...
متن کاملHereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome.
BACKGROUND Hereditary nonpolyposis colorectal cancer HNPCC, Lynch syndrome) is a genetic disease of autosomal dominant inheritance. It is caused by a mutation in one of four genes of the DNA mismatch repair system and confers a markedly increased risk for various types of cancer, particularly of the colon and the endometrium. Its prevalence in the general population is about 1 in 500, and it ca...
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ژورنال
عنوان ژورنال: Hereditary Cancer in Clinical Practice
سال: 2010
ISSN: 1897-4287
DOI: 10.1186/1897-4287-8-s1-p12